منابع مشابه
Differential effects of antihypertensive drug therapy on arterial compliance.
Although vascular compliance, deltaV/deltaP, is abnormal in essential hypertension and can be improved by antihypertensive drug therapy, it is not clear whether drug-induced changes in compliance are attributable solely to lower achieved blood pressure (BP), and thus equally likely with different drugs possessing similar antihypertensive efficacy. Therefore, we used computerized arterial pulse ...
متن کاملPharmacodynamic effects of a new antihypertensive drug, Catapres (ST-155).
Catapres is a new imidazoline compound with potent antihypertensive properties. Significant reduction in blood pressure occurs between 1 and 4 hours after oral administration, with the peak effect occurring at 2 to 4 hours and the antihypertensive effect extending for 6 to 10 hours. Blood pressure is reduced in both the supine and erect positions, although the orthostatic response is the more p...
متن کاملDrug interactions of antihypertensive agents
Adverse drug-drug interactions may occur when a major therapeutic mechanism of one drug class (such as bradycardia with a beta blocker) is excessively exaggerated by the addition of another heart-rate slowing antihypertensive, such as verapamil. The most important interactions at the molecular level are those of the hepatic enzyme, cytochrome (CYP) 3A4. A classic example is the inhibitory effec...
متن کاملPersistence to antihypertensive drug classes
The aim was to study persistence to, and switching between, antihypertensive drug classes and to determine factors associated with poor persistence.This was an observational cohort study. The Swedish Primary Care Cardiovascular Database includes data from medical records, socioeconomic data, filled prescriptions, and hospitalizations from national registries for 75,000 patients with hypertensio...
متن کاملTrends in antihypertensive drug treatment.
To the Editor: It is disappointing to read once again that “b-blockers and thiazide diuretics are the only antihypertensive agents that have been shown to reduce cardiovascular mortality.”1 In these days of evidence-based medicine, we must ask: where is the evidence for this statement? The basic data referenced by Wang et al1 are those of the meta-analysis of Psaty et al,2 which are also shown ...
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ژورنال
عنوان ژورنال: Nature Reviews Rheumatology
سال: 2018
ISSN: 1759-4790,1759-4804
DOI: 10.1038/nrrheum.2018.25